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REUNITING WITH MY BEST FRIEND

howdoiputthisgently:

FIRST I’M LIKE:

AND THEN WE’RE LIKE:

AND THEN OF COURSE WE’RE LIKE:

1,638 notes / 1 day ago / Reblog

I feel like the word ninja should have a silent k

1 week ago / Reblog

im gonna donate my body to science so they can discover how one person can have so many cool cells.

(via rhydonmyhardon)

5,374 notes / 1 week ago / Reblog

nerd humor.

(via quasiwhitegirl)

47,963 notes / 1 week ago / Reblog

173

neurosciencestuff:

Scientists develop drug that slows Alzheimer’s in mice
A drug developed by scientists at the Salk Institute for Biological Studies, known as J147, reverses memory deficits and slows Alzheimer’s disease in aged mice following short-term treatment. The findings, published May 14 in the journal Alzheimer’s Research and Therapy, may pave the way to a new treatment for Alzheimer’s disease in humans.
“J147 is an exciting new compound because it really has strong potential to be an Alzheimer’s disease therapeutic by slowing disease progression and reversing memory deficits following short-term treatment,” says lead study author Marguerite Prior, a research associate in Salk’s Cellular Neurobiology Laboratory.
Despite years of research, there are no disease-modifying drugs for Alzheimer’s. Current FDA-approved medications, including Aricept, Razadyne and Exelon, offer only fleeting short-term benefits for Alzheimer’s patients, but they do nothing to slow the steady, irreversible decline of brain function that erases a person’s memory and ability to think clearly.
According to the Alzheimer’s Association, more than 5 million Americans are living with Alzheimer’s disease, the sixth leading cause of death in the country and the only one among the top 10 that cannot be prevented, cured or even slowed.
J147 was developed at Salk in the laboratory of David Schubert, a professor in the Cellular Neurobiology Laboratory. He and his colleagues bucked the trend within the pharmaceutical industry, which has focused on the biological pathways involved in the formation of amyloid plaques, the dense deposits of protein that characterize the disease. Instead, the Salk team used living neurons grown in laboratory dishes to test whether their new synthetic compounds, which are based upon natural products derived from plants, were effective at protecting brain cells against several pathologies associated with brain aging. From the test results of each chemical iteration of the lead compound, they were able to alter their chemical structures to make them much more potent. Although J147 appears to be safe in mice, the next step will require clinical trials to determine whether the compound will prove safe and effective in humans.
“Alzheimer’s disease research has traditionally focused on a single target, the amyloid pathway,” says Schubert, “but unfortunately drugs that have been developed through this pathway have not been successful in clinical trials. Our approach is based on the pathologies associated with old age-the greatest risk factor for Alzheimer’s and other neurodegenerative diseases-rather than only the specificities of the disease.”
To test the efficacy of J147 in a much more rigorous preclinical Alzheimer’s model, the Salk team treated mice using a therapeutic strategy that they say more accurately reflects the human symptomatic stage of Alzheimer’s. Administered in the food of 20-month-old genetically engineered mice, at a stage when Alzheimer’s pathology is advanced, J147 rescued severe memory loss, reduced soluble levels of amyloid, and increased neurotrophic factors essential for memory, after only three months of treatment.
In a different experiment, the scientists tested J147 directly against Aricept, the most widely prescribed Alzheimer’s drug, and found that it performed as well or better in several memory tests.
“In addition to yielding an exceptionally promising therapeutic, both the strategy of using mice with existing disease and the drug discovery process based upon aging are what make the study interesting and exciting,” says Schubert, “because it more closely resembles what happens in humans, who have advanced pathology when diagnosis occurs and treatment begins.” Most studies test drugs before pathology is present, which is preventive rather than therapeutic and may be the reason drugs don’t transfer from animal studies to humans.
Prior and her colleagues say that several cellular processes known to be associated with Alzheimer’s pathology are affected by J147, including an increase in a protein called brain-derived neurotrophic factor (BDNF), which protects neurons from toxic insults, helps new neurons grow and connect with other brain cells, and is involved in memory formation. Postmortem studies show lower than normal levels of BDNF in the brains of people with Alzheimer’s.
Because of its broad ability to protect nerve cells, the researchers believe that J147 may also be effective for treating other neurological disorders, such as Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis (ALS), as well as stroke, although their study did not directly explore the drug’s efficacy as a therapy for those diseases.
The Salk researchers say that J147, with its memory enhancing and neuroprotective properties, along with its safety and availability as an oral medication, would make an “ideal candidate” for Alzheimer’s disease clinical trials. They are currently seeking funding for such a trial.
(Marguerite Prior, Richard Dargusch, Jennifer L Ehren, Chandramouli Chiruta and Dave Schubert. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer’s disease mice. Alzheimer’s Research & Therapy, 2013 (in press))

elphabaforpresidentofgallifrey:

joelbyeman:

I feel like people in horror movies live in an alternate universe where there are no horror movies

That explains a lot

62,365 notes / 1 week ago / Reblog

"Marry your best friend. I do not say that lightly. Really, truly find the strongest, happiest friendship in the person you fall in love with. Someone who speaks highly of you. Someone you can laugh with. The kind of laughs that make your belly ache, and your nose snort. The embarrassing, earnest, healing kind of laughs. Wit is important. Life is too short not to love someone who lets you be a fool with them. Make sure they are somebody who lets you cry, too. Despair will come. Find someone that you want to be there with you through those times. Most importantly, marry the one that makes passion, love, and madness combine and course through you. A love that will never dilute - even when the waters get deep, and dark."

- N’tima (via kevinidentity)

(Source: mariaarroyo, via dangerousinthedark)

91,251 notes / 1 week ago / Reblog

ruffaloon:

omfg my mom dropped her iphone in the toilet so she fished it out and desperately yelled ‘SIRI I DROPPED YOU IN THE TOILET WHAT DO I DO’ and siri replied ‘Tara, you have 28 events in July. That’s a lot.’ and then died

#more dramatic than romeo and juliet

(Source: grintaire, via sacajewea)

171,803 notes / 1 week ago / Reblog

jensensations:

Ryan Gosling won’t eat his cereal (x)

BABY PLEASE YOU HAVE TO EAT SOMETHING

281,114 notes / 2 weeks ago / Reblog

43711

“Noah was desperate. He wrote to Allie that he was sorry and stupid for breaking up with her. He wrote to tell her that he still loved her, and he wanted to see her. And that if she would write back, he would come to wherever she was. He wrote one letter everyday for a year — 365 letters, but they all went unanswered. Finally, after a year of silence, he decided to put it all behind him and start a new life. So he wrote a farewell letter.”

(Source: swiftlovatorauhl, via fuckyeahmcgosling)

3,235 notes / 2 weeks ago / Reblog

4

#masterchem likes to describe me doing complex science experiments in my backyard and getting really excited. #stoptryingsohard #chemistry #finals #sodone

we’d probably already have hoverboards if we didn’t spend so much time arguing over whether women are people and if they should be allowed to do science

(via ashitanoyuki)

45,934 notes / 2 weeks ago / Reblog

do the people running the facebook pages everyone liked back in 2009 truly believe that they are doing a good thing

(via greatwhiteprivilege)

282 notes / 2 weeks ago / Reblog

0

@kfquinn11 drew me a #babyhippo and its #mama! #presh #hippos #boyfriend #drawing #cute #artist #cutestcouple #dormdeco #animals #sweet